Wednesday, December 03, 2008

Dichloroacetate - Pulmonary Hypertension

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Enhanced ETA-receptor-mediated inhibition of Kv channels in hypoxic
R. Waite, and S. L. Archer Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats...

Molecular Identification of the Role of Voltage-gated K+ Channels,
K+ Channels, Kv1.5 and Kv2.1, in Hypoxic Pulmonary Vasoconstriction and Control of Resting Membrane Potential in Rat Pulmonary Artery Myocytes

Efficacy of Dichloroacetate as a Lactate-Lowering Drug -- Stacpoole
Haromy, K. Hashimoto, and E. D. Michelakis Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth...

CCS ORAL SESSION: BASIC SCIENCE III - ATHEROSCLEROSIS
340 - DICHLOROACETATE INHIBITS MONOCROTALINE PULMONARY HYPERTENSION IN RATS MS McMurtry, SL Archer, ED Michelakis. Edmonton, AB

Sustained membrane depolarization and pulmonary artery smooth muscle
...pulmonary vascular resistance in patients with pulmonary hypertension (42, 58). PASMC from patients with primary pulmonary hypertension (PPH...

Sustained membrane depolarization and pulmonary artery smooth muscle
R. Waite, and S. L. Archer Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats...

Molecular Identification of the Role of Voltage-gated K+ Channels,
Haromy, K. Hashimoto, and E. D. Michelakis Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth...

Bone morphogenetic proteins induce apoptosis in human pulmonary
...pulmonary vascular resistance and pulmonary arterial pressure (PAP) found in patients with primary pulmonary hypertension (PPH). The pulmonary...

Enhanced ETA-receptor-mediated inhibition of Kv channels in hypoxic
-receptor blockers to attenuate the development of hypoxic pulmonary hypertension in vivo. pulmonary hypertension; ion channel; potassium channel;

Alterations in a redox oxygen sensing mechanism in chronic hypoxia
CH pulmonary hypertension was confirmed in anesthetized (pentobarbital sodium;