Wednesday, December 03, 2008

Doca Model

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Endothelin antagonist reduces hemodynamic responses to vasopressin
...of hypertension in the DOCA-salt model. However, remodeling does not appear to fully explain the enhanced vascular responsiveness of DOCA-salt...

Increased renal medullary endothelin-1 synthesis in prehypertensive
...system in a DOCA- and salt-treated rat model. Male Wistar rats were divided into control and DOCA- and salt-treated (DOCA-Salt) groups. The DOCA...

Role of endothelin and vasopressin in DOCA-salt hypertension -- Yu
...the early stages (24 – 31 days) of development of hypertension in the conscious deoxycorticosterone acetate (DOCA)-salt hypertensive rat model.

Cardiac Microvasculature in DOCA-Salt Hypertensive Rats : Effect of
...of the heart, we studied cardiac microvessels of the deoxycorticosterone acetate–salt (DOCA-salt) model of hypertension in the rat, in which...

Role of Dietary Potassium in the Hyperaldosteronism and Hypertension
...with a full complement of nephrons (18,34). Indeed, the classic mineralocorticoid—salt or "DOCA-salt"—model of hypertension requires nephron...

Endothelin antagonist reduces hemodynamic responses to vasopressin
...suggest that endothelin contributes to the hemodynamic effects of vasopressin but not angiotensin II in the DOCA-salt model of hypertension.

Endothelin-1 and CYP450 arachidonate metabolites interact to promote
1 may be an additional factor in activating CYP450 enzymes that produce AA metabolites (25, 26). The DOCA-salt model of hypertension has been...

Coronary vascular reactivity is improved by endothelin A receptor
A-127722 enhances coronary vascular reactivity to ET-1 in a manner that may improve coronary function in the DOCA-salt model of hypertension.

Blood Pressure, Cardiac, and Renal Responses to Salt and
...of hypertension in mice, the DOCA/salt model was developed in one- and two-renin gene mice. The deoxycorticosterone/salt hypertension model is...

Endothelin-1-induced venous contraction is maintained inDOCA-salt
A sustained response to ET-1 in the venous circulation may contribute to the elevated blood pressure in the DOCA-salt model.